ANTI-PLA2R ANTIBODY MOUSE MONOCLONAL

Code: SAB4200757-100UL D2-231

Application

Anti-PLA2R antibody has been used in immunoblotting immunofluorescence flow Cytometry immunohistochemistry

Biochem/physiol Actions

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€552.00 100UL
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Application

Anti-PLA2R antibody has been used in immunoblotting immunofluorescence flow Cytometry immunohistochemistry

Biochem/physiol Actions

Secretory phospholipase A2 receptor (PLA2R) acts as a receptor for secretory phosholipase A2 (sPLA2) allowing its removal from circulation, thus regulating its biological effect. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipase A2 (sPLA2) from the blood, including group sPLA2-X and a snake venom sPLA2. The soluble circulating form of PLA2R is constitutively present as an endogenous inhibitor of sPLA2s. PLA2R is expressed in kidney podocytes of normal human glomeruli, in idiopathic membranous nephropathy (IMN) patients PLA2R is colocalized to immune deposits in glomeruli along with IgG4.

General description

Anti-PLA2R antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the 12-6-5 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with recombinant fragment of human PLA2R corresponding to extracellular sequence NC3. Secretory phospholipase A2 receptor (PLA2R) is 180 kDa and is a type I transmembrane glycoprotein member of the mannose receptor (MR) family. Large extracellular glycosylated region comprising an N-terminal cysteine-rich domain (CysR), a fibronectin-like type II domain (FnII), and eight to ten C-type lectin-like domains (CTLD).

Immunogen

Human PLA2R extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

antibody formpurified from hybridoma cell culture
antibody product typeprimary antibodies
biological sourcemouse
clone12-6-5, monoclonal
concentration~1 mg/mL
formbuffered aqueous solution
Gene Informationhuman ... PLA2R1(22925)
isotypeIgG2b
mol wt~180 kDa
Quality Level200
shipped indry ice
species reactivityhuman
storage temp.−20°C
technique(s)immunoblotting: 1-2 µg/mL using partial recombinant human PLA2R1 protein (predicted ~150kDa), flow cytometry: suitable, immunohistochemistry: suitable, immunofluorescence: suitable
UniProt accession no.Q13018
This product has met the following criteria to qualify for the following awards:



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